Research Paper : The Effects of Geranium Oil on the Inhibition of Skin Aging in Hairless Mice(1) -Focussed on Gross Examination-

Kim, Young Chul; Min, Kyung Jin; Sin, Jung Sub; Gang, Sung Rye; Kim, Pil Sun

Journal of the Korean Society of Cosmetology 2008;14(2):495-503.
Published online June 30, 2008.

Hairless 마우스에서 제라늄 오일의 피부노화 억제 효과(1) -육안적 관찰을 중심으로-

김영철, 민경진, 신정섭, 강성례, 김필순

Research Paper : The Effects of Geranium Oil on the Inhibition of Skin Aging in Hairless Mice(1) -Focussed on Gross Examination-

Young Chul Kim, Kyung Jin Min, Jung Sub Sin, Sung Rye Gang, Pil Sun Kim

Abstract

To evaluate the skin aging inhibition effect of geranium oil, skin aging animal model was produced by both the irradiation of UVB and the application of squalene-OOH to SHR-1 hairless mice for 4 weeks. And at the same time 3% of geranium oil diluted in jojoba oil was applied topically. The skin erythema index for the positive control group and geranium oil application group were lower than that of the control. Whereas, both the lipid capacity and water capacity for the positive control group and geranium oil application group were higher than those of the control. Wrinkles for the control group were formed as a pattern of deep furrows and thick crests. Whereas, wrinkles for the positive control group and experimental group were formed as a pattern of shallow furrows and thin crests which were similar to that of the normal group. As for the both absolute and relative weight of the spleen, the positive control group were significantly higher than the other groups. In conclusion, geranium oil can be used practically for the prevention or improvement of skin aging in terms of health promotion and beauty for the people.

Key Words: Geranium Oil, Hairless Mice, Skin Aging, Wrinkles, Lipid Capacity